During the Civil War, Lloyd was an important stop on the Pensacola and Georgia Railroad, which ran from Lake City to Gee's Turnout near Quincy, for the transportation of Confederate soldiers and war materials as well as cotton and foodstuffs from Middle Florida's rich agricultural lands.

After the February 1864 Battle of Olustee, some wounded Confederate soldiers were unloaded at the Lloyd Railroad Depot and treated in a make-shift hospital by local women in at least one private residence, the c.1855 Lloyd-Bond House.

Two of their patients died and are buried on nearby Bond family land.

Information Provided by the Florida Department of State.